CCB 219 The protein homeostasis network in normal and disease states (2016)

Module: 3
Sponsoring Program: CCB
Administrator: Julia Molla

Course Number: CCB 219
Course Name: The protein homeostasis network in normal and disease states
Units: 3
Grading Option: S/U
Course Director: Jason Gestwicki

Additional Course Director(s): Martin Kampmann
Room Number: BH-215
Campus: Mission Bay
Schedule: May 9-May 27, 2016; M, W, F; 9:00-11:00 AM
Prerequisites: None
Maximum Class Size: 15

Course Description: Cells and organisms maintain their protein homeostasis (aka proteostasis) by carefully regulating protein production, quality control and turnover. This delicate balance is achieved through the action of many conserved pathways, including translational control, stress responses, degradation systems and molecular chaperones. In healthy cells, these pathways assist each protein "from the cradle to the grave" - from its initial folding to its eventual turnover through the proteosome or lysosome. However, imbalances in proteostasis are also linked to many diseases, including cancer and neurodegeneration. Indeed, a collapse in proteostasis has been associated with aging in many model systems, suggesting that there is a close interplay between proteostasis and aging-associated diseases. In this course, we will introduce the fundamental concepts of proteostasis and review the most exciting, recent developments. Experts in proteotasis will provide insights into the tools and ideas that are driving the field. Finally, through team-based learning, we will dive deeper into the roles of proteostasis in disease and discuss the emerging ways that this knowledge could be used to treat them.